Rigorous radiolabelling validation methods to ensure that images are correctly interpreted are essential. To achieve this goal all of our data processing methods are verified and accurate corrections for tissue attenuation in different body regions are calculated on a subject-by-subject basis. A complete electronic data trail from raw image file to attenuation, decay and background corrected data forms part of our standard reporting procedure.

Particular expertise exists in the evaluation of inhaler systems, especially in the development and validation of radiolabelling methods for dry powder inhaler (DPI) formulations and also both HFA and CFC based pressurised metered dose inhalers (pMDI).

Our lung imaging protocols include Krypton-81m gas ventilation scans to ensure accurate definition of lung margins. Transmission imaging is used to derive individual tissue attenuation correction factors. Mass balance studies have proven the accuracy of our procedures.

 

Case Studies:

       
Whole body transmission imaging to enable accurate determination of regional tissue attenuation factors to aid quantitation of radiolabel bio-distribution Wholebody transmission imaging to enable accurate determination of regional tissue attenuation factors to aid quantitation of radiolabel bio-distribution   lungs viewed using gamma camera A Kr-81m gas ventilation image of a healthy subject. The inhalation of this inert gas permits accurate determination of the lung margins using an autocontour function.