Application

The successful application of scintigraphy is dependent on direct or indirect labelling of a component of the dosage form with a suitable gamma-emitting radioisotope such as Technetium-99m or Indium-111.

Depending upon the study objectives, protocols may include whole body and regional imaging using planar scintigraphy, or SPECT techniques. The scintigraphic analysis can also be complimented with expertise in pharmacokinetic and pharmacodynamic evaluations, drug assay development and bio-analysis.

In the respiratory tract the performance of delivery systems is assessed by evaluation deposition and residence in the oropharyngeal and central and peripheral regions of the lung. Furthermore, physiological functions such as mucociliary clearance may be studied using this technique. Gamma scintigraphy is also routinely used to characterise drug delivery from oral dosage forms, factors such as gastric residence / emptying, gastrointestinal transit and the site of disintegration/dispersion can be determined.

Application

The successful application of scintigraphy is dependent on direct or indirect labelling of a component of the dosage form with a suitable gamma-emitting radioisotope such as Technetium-99m or Indium-111.

Depending upon the study objectives, protocols may include whole body and regional imaging using planar scintigraphy, or SPECT techniques. The scintigraphic analysis can also be complimented with expertise in pharmacokinetic and pharmacodynamic evaluations, drug assay development and bio-analysis.

In the respiratory tract the performance of delivery systems is assessed by evaluation deposition and residence in the oropharyngeal and central and peripheral regions of the lung. Furthermore, physiological functions such as mucociliary clearance may be studied using this technique. Gamma scintigraphy is also routinely used to characterise drug delivery from oral dosage forms, factors such as gastric residence / emptying, gastrointestinal transit and the site of disintegration/dispersion can be determined.