Gamma scintigraphy provides clinicians and researchers with direct, visual, and quantitative information about how a formulation/drug behaves inside the body. This can be crucial when clinical results are unexpected or don’t match predictions from laboratory tests.

Key Ways It Helps
Reveals In Vivo Drug Behavior: Gamma scintigraphy can show whether a drug formulation is behaving as expected inside the body. For example, it can confirm if an oral tablet is releasing its drug at the right place and time in the gastrointestinal tract, or if an inhaled drug is reaching the intended region of the lungs.

Identifies Issues with Drug Delivery: If clinical results are unusual—such as lower than expected efficacy or unexpected side effects—scintigraphy images can help identify if the drug is not reaching its target site, is being cleared too quickly, or is depositing in unintended areas.

Assesses Impact of Patient Factors: The technique can help determine if factors like patient technique, posture, or physiological differences are affecting drug delivery and performance, which might explain variability in clinical outcomes.

Validates or Refines Hypotheses: By comparing in vivo imaging data to in vitro predictions, clinicians can see if a formulation’s real-world performance matches expectations, helping to pinpoint the cause of unexpected results.

Supports Troubleshooting and Optimization: The clear, quantitative data from gamma scintigraphy allow teams to make informed decisions about formulation or device changes to address clinical issues.

In Summary: Gamma scintigraphy helps clinicians and scientists understand unexpected clinical data by visually confirming where and how much drug is delivered in the body, revealing issues with drug delivery, and supporting rapid troubleshooting and optimization.